/hrt/masculinizing
Masculinizing HRT
Rev: 2025.12
Overview
Masculinizing hormone therapy involves testosterone administration. The goal is to achieve male typical testosterone levels: 300-1000 ng/dL (trough) depending on individual goals.
DESCRIPTION
Masculinizing HRT induces the development of male secondary sex characteristics. Effects include voice deepening, facial hair growth, increased muscle mass, fat redistribution, body hair growth, and clitoral growth. Most changes are permanent.
EXPECTED EFFECTS
| Effect | Onset | Maximum | Reversible |
|---|---|---|---|
| Voice deepening | 3-12 months | 1-2 years | No |
| Facial hair | 6-12 months | 4-5 years | No |
| Body hair | 6-12 months | 4-5 years | No |
| Increased muscle mass | 6-12 months | 2-5 years | Yes |
| Fat redistribution | 3-6 months | 2-5 years | Yes |
| Clitoral growth | 3-6 months | 1-2 years | No |
| Cessation of menses | 2-6 months | — | Yes |
| Scalp hair loss | 6-12 months | Variable | Varies |
MEDICATIONS
Testosterone (Overview)[testosterone]
Primary androgen for masculinizing hormone therapy. Available in various ester formulations for injection, as well as topical gels and creams.
Testosterone Cypionate[testosterone]
Long-acting injectable testosterone, typically injected every 7-14 days
Testosterone Enanthate[testosterone]
Injectable testosterone ester, similar profile to Cypionate
Testosterone Undecanoate[testosterone]
Very long-acting testosterone ester. Injectable form is typically in MCT oil and allows for very infrequent dosing. Also available as oral capsules.
TARGET HORMONE LEVELS
Total Testosterone (trough)
300-1000 ng/dL
Measured before next injection
Hematocrit
<54%
Monitor for polycythemia
RELATED
Rev: 2025.12hrt.fm